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“The main concern is the credibility of the guidelines, regardless if the claims are valid or not,” Lopez-Jiminez said.
“These guidelines have been vetted by multiple experts many, many times,” AHA President Dr. Mariell Jessup said.
It said that he “strongly supports the key messages of the new guidelines and believes that questions raised about the risk calculator should be relatively easy to address. Dr. Ridker is an advocate of expanded statin use in primary prevention, a major advance of the new ACC/AHA guidelines.”
“We used what we thought were the best available data” to determine the new guidelines, Lloyd-Jones said. “We’d all like to see Dr. Ridker’s data instead of seeing this played out in the media.”
The guidelines authors said Ridker notified them on Friday of his criticisms for the first time, and that they would appear in the Lancet.
“We think we came up with a good risk assessment instrument,” Smith said.
“We got his review and he did not say anything about these three population studies at that time,” Goff said.
“We intend to move forward with the implementation of these guidelines,” said Dr. Sidney Smith of the University of North Carolina, a past president of the AHA who was executive chairman of the guidelines committee.
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Nevertheless, I think this is a goo post for other people but please explain somewhere that the theory s right! people should stop using big Oh until the really understand it meaning and the algorithm implementation…
Even though this version has to calculate potentially unneeded values it is still significantly faster, as we shall see.
However, this version takes ~0.7 s, rather than ~0.44, I believe because of the first loop. It can be probably optimized through some fancy instruction, though. Otherwise, it’s still the best version for arrays of size 2^n.
As far as linear search is concerned, it pays off to unroll and it pays off to use sentinels. The best non-sentinel linear search I tested unrolls the loop first 8 times and then 4 times. This search in turn is beaten handily across the board by a 32 times unrolled linear search with a sentinel. I have not tested longer unrollings than 32 for the sentinel search. On AMD CPUs, unrolling 32 times is a bit slower than unrolling 16 times, though, while for the Intel CPUs they’re at about the same speed.
Each iteration here also does two unconditional branches, one of which is essentially unpredictable. There’s no way for the CPU to know in which of the two halves of the search space the element you’re looking for will be, which means that we’ll get on average one branch misprediction per two iterations.
Now we’re down to one conditional and one unconditional branch per iteration. By unrolling we can reduce the unconditional branch to a fraction. Note that with a sentinel we don’t need an end-check even with unrolling, so searches through very small arrays also benefit from unrolling.
Did you really have to write the code?!? Common that is what big Oh notation is for. There main problem people are having is to truly understand what big Oh means. What I mean is the following, we know as a fact that a linear search is O(n) while a binary search is O(log N), of course if we do not understand our algorithm (in this case binary search) we will thing that O(log N) will always outperform O(N) but that is not true.
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The Weekly News Roundup is your weekly recap of CBOE features, options industry news and VIX Index and volatility-related articles from print, broadcast, online and social media outlets. VIX Fix: “Fire and Fury” in the Markets As the war of words between the U.S. and North Korea escalated this week, major market indicators, fresh off record highs, tumbled, while volatility, complacent most of the summer, surged. The CBOE Volatility Index (VIX) spiked 44% on Thursday,
Since the election the stock market has been on a roll, and even bonds have shown strength. We are just about finished with second quarter earnings reports and we have seen some solid surprises to the upside, a near 10% gain in earnings over 2016. This follows another double digit gain from first quarter, and some estimates have the second half of 2017 coming in with double digit gains. This will help buoy the markets until the earnings cycle inflects to the downside. That
We are in the midst of August, the "dog days of summer", and all we hear about now is a 'seasonally weak' period for markets. History is on the side of these commenters, yet maybe things are a bit different today. Let's flesh it out and see if we can take advantage. August seems to get the blame for many bad things to come. There are no 'pure' or 'fun' holidays in August, and in the northern hemisphere it is usually the hottest time of the year (weather-wise). As it relates
The Weekly News Roundup is your weekly recap of CBOE features, options industry news and VIX Index and volatility-related articles from print, broadcast, online and social media outlets. VIX Fix: Volatility on Ice Markets ended the week mixed after a steep drop on more geopolitical fears. Now that tough talk between President Trump and North Korea has simmered, markets have since rebounded. The CBOE Volatility Index (VIX) saw a pop early in the week to over
Other trades of note: ViewRay, Inc. (VRAY) at 4.61, a 1x2 Ratio Spread traded. The trader bought 900 Sept 15th 5 Calls for .50 and sold 1,800 Sept 15th 7.50 Calls at .05. They paid .40 for the package. iShares Russell 2000 ETF (IWM) at 141.38, a Bear Put Spread traded 15,000 times. The trader bought the Aug 4th 141/138 spread paying .53. Exxon Mobil Corporation (XOM) at 79.87, a Bull Call Spread traded 1,000 times. The trader bought the Aug 4th 80/80.50 spread paying .22. XOM reported earnings
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4. Over time sediment builds up. This can create small islands that split the channel in the same was as braided streams;
Deltas are landforms formed at the mouth of a river, where the river meets a body of water with a lower velocity than the river (e.g. lake or sea), resulting in the reduction in the river’s capacity to transport sediment.
Deltas are formed in the following way:
6. If sediment is fine grained bird’s foot deltas can be created. If sediment is coarse grained arcuate deltas form.
2. At the mouth of the river the flow of water becomes increasingly lateral. This lateral movement of water reduces hydraulic radius and increases wetted perimeter;
5. This continues until the river splits as more islands form;
Deltas are dynamic areas that change quickly due to the erosion of unstable land during storm and flood events and the creation of new land. Deltas are fertile areas which often support large populations due to their agricultural productivity. Examples include the Ganges delta in Bangladesh and the Nile delta in Egypt.
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This is not the best way of doing business. In our experiences here at Binary Today, the only developers we’ve seen operate in an e-mail to purchase method are swindlers. They gauge the interest of the emailer and then negotiate a price. We’ve seen developers like these sell the same indicators to one person for $1000 and others under $100.
I want get this indicator, but somebody know if really works?
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Each strategy comes with a brief explanation and often a video preview. The instructions are simple, traders are required to monitor the MetaTrader 4 charts and follow on chart indications. Some of the strategies have multiple rules. For example, the 60 second strategy requires that traders only “take a trade if the previous candle is having a star on it.”
The Binary Diaries web-site’s main objective is to get traders to purchase their Grail Indicators package, but the process in doing so seems oddly difficult. Unless we are navigating the pages incorrectly, there doesn’t seem to be a price or purchase page available. It does seem as though, the only way to gain access is to email the development team at [email protected]
Hi Julius, can you show us some examples? 80% accuracy is a very difficult number to achieve for any trader, or system.
The web-site isn’t the most professional we’ve ever covered. The background images are too loud and the majority of the Binary Diaries sales page comes across as quite unprofessional. There are two types of articles on the site, binary options broker reviews and binary options strategies using the Grail Indicators. There are currently 7 strategies available.
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There has been some media speculation that Collison, a friend of 40-year-old OKC general manager Sam Presti, might be interested in joining the Thunder front office or Billy Donovan’s coaching staff as an assistant coach in the wake of Thunder assistant Anthony Grant becoming head coach at University of Dayton.
Moving from franchise to franchise can be difficult. You can partially chalk Oladipo’s regression up to his lack of familiarity with his teammates. As for the other portion of the blame, that’ll be dispersed to Kevin Durant.
Apr 19, 2017; Houston, TX, USA; Oklahoma City Thunder forward Nick Collison (4) on the bench during the third quarter against the Houston Rockets in game two of the first round of the 2017 NBA Playoffs at Toyota Center. Mandatory Credit: Erik Williams-USA TODAY Sports
The 36 year old veteran has lost so much blood for the team, I would rather Collison fill a roster slot than Kyle Singler.
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The rearrangement of the alpha (α) chain of the TCR follows β chain rearrangement, and resembles V-to-J rearrangement described for Ig light chains (see above). The assembly of the β- and α- chains results in formation of the αβ-TCR that is expressed on a majority of T cells.
The process of V(D)J recombination is mediated by VDJ recombinase, which is a diverse collection of enzymes. The key enzymes involved are recombination activating genes 1 and 2 (RAG), terminal deoxynucleotidyl transferase (TdT), and Artemis nuclease, a member of the ubiquitous non-homologous end joining (NHEJ) pathway for DNA repair. 7 Several other enzymes are known to be involved in the process and include DNA-dependent protein kinase (DNA-PK), X-ray repair cross-complementing protein 4 (XRCC4), DNA ligase IV, non-homologous end-joining factor 1 (NHEJ1; also known as Cernunnos or XRCC4-like factor ), the recently discovered Paralog of XRCC4 and XLF (PAXX), and DNA polymerases λ and μ. 8 Some enzymes involved are specific to lymphocytes (e.g., RAG, TdT), while others are found in other cell types and even ubiquitously (e.g., NHEJ components).
In 1987, Susumu Tonegawa was awarded the Nobel Prize in Physiology or Medicine 1 "for his discovery of the genetic principle for generation of antibody diversity".
Human antibody molecules (and B cell receptors) are composed of heavy and light chains (each of which contains both constant (C) and variable (V) regions), which are encoded by genes on three loci:
In the developing B cell, the first recombination event to occur is between one D and one J gene segment of the heavy chain locus. Any DNA between these two gene segments is deleted. This D-J recombination is followed by the joining of one V gene segment, from a region upstream of the newly formed DJ complex, forming a rearranged VDJ gene segment. All other gene segments between V and D segments are now deleted from the cell’s genome. Primary transcript (unspliced RNA) is generated containing the VDJ region of the heavy chain and both the constant mu and delta chains (Cμ and Cδ). (i.e. the primary transcript contains the segments: V-D-J-Cμ-Cδ). The primary RNA is processed to add a polyadenylated (poly-A) tail after the Cμ chain and to remove sequence between the VDJ segment and this constant gene segment. Translation of this mRNA leads to the production of the Ig μ heavy chain protein.
The coding ends are processed further prior to their ligation by several events that ultimately lead to junctional diversity. 18 Processing begins when DNA-PK binds to each broken DNA end and recruits several other proteins including Artemis, XRCC4, DNA ligase IV, Cernunnos, and several DNA polymerases. 19 DNA-PK forms a complex that leads to its autophosphorylation, resulting in activation of Artemis. The coding end hairpins are opened by the activity of Artemis. 20 If they are opened at the center, a blunt DNA end will result; however in many cases, the opening is "off-center" and results in extra bases remaining on one strand (an overhang). These are known as palindromic (P) nucleotides due to the palindromic nature of the sequence produced when DNA repair enzymes resolve the overhang. 21 The process of hairpin opening by Artemis is a crucial step of V(D)J recombination and is defective in the severe combined immunodeficiency (scid) mouse model.
The kappa (κ) and lambda (λ) chains of the immunoglobulin light chain loci rearrange in a very similar way, except that the light chains lack a D segment. In other words, the first step of recombination for the light chains involves the joining of the V and J chains to give a VJ complex before the addition of the constant chain gene during primary transcription. Translation of the spliced mRNA for either the kappa or lambda chains results in formation of the Ig κ or Ig λ light chain protein. Interestingly, the immunoglobulin lambda light chain locus contains protein-coding genes that can be lost with its rearrangement. 4 This is based on a physiological mechanism and is not pathogenetic for leukemias or lymphomas. 4 However, the rearrangement of several lambda variable subgenes can activate expression of an overlapping miRNA gene, which has consequences for gene expression regulation. 5
Lastly, exonucleases can remove bases from the coding ends (including any P or N nucleotides that may have formed). DNA polymerases λ and μ then insert additional nucleotides as needed to make the two ends compatible for joining. This is a stochastic process, therefore any combination of the addition of P and N nucleotides and exonucleolytic removal can occur (or none at all). Finally, the processed coding ends are ligated together by DNA ligase IV. 24
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The Laptop Debate: Computers in the College Classroom What Does a Typical College Class Schedule Look Like? How Are College Classes Structured? The College Dean’s List Prestigious College Scholarships: The Fulbright, Truman, Marshall, and Rhodes Scholarships Taking Notes in College Renting, Buying, and Selling Your College Textbooks College Tutoring
Most four-year colleges and universities have media rental centers and/or classrooms equipped with multimedia hardware and software.
One up and coming movement in California is Open Source Textbooks, which advocates providing textbook access to students digitally, printable or in the more traditional format. This idea was based on the fact that the average college student spends $900 per year on new textbooks. Using open source textbooks allows students to save $716.
Abilene Christian University in Texas gives each freshmen a new IPhone or IPod Touch. Professors at the school are encouraged to incorporate these technologies into their curriculum. For example, a drama teacher might record a video of the lead dancer in a production and send it to students for rehearsal.